From DrugPedia: A Wikipedia for Drug discovery

Immunotation of Rv2753c (dihydrodipicolinate synthase)
Name
Dihydrodipicolinate Synthase
Identifiers
Swiss Prot	P63945
Genbank	888289
PDB	1XXX
Chemical data
Formula	C28H37ClN4O6 [1]
Mol. wt.	30,858 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	5.57

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Antigens 3.1 Epitopes 3.1.1 B-Cell Epitopes 3.1.1.1 BCEpred 3.1.1.2 ABCpred Results 3.1.2 IEBB Analysis

General

dapA catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate.

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2H₂O.

This protein is eesential for optimal growth of M.tb and found in the cytoplasm as predicted by the WoLFPSORT and Subloc Server. HMMpfam found one domain PF00701 and has Helix Turn Helix secondary structure.

Protein Sequence

>Rv2753c, TB.seq 3066222:3067121 MW:30827 VTTVGFDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTTGESPTTTDGEKIELLRAVLEAVGDR ARVIAGAGTYDTAHSIRLAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEPDTIRA LASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKI NIAVAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR

Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q9BXD5	28	46.33	300	3.00E-023
sp|Q86XE5	26.57	46.15	286	4.00E-022
sp|Q9UG63	26.49	37.75	151	0.45
sp|O14556	22.09	50	86	2
sp|Q7Z7B0	27.69	44.62	65	2.7

Antigens

Epitopes

B-Cell Epitopes

BCEpred

Result Predicted by bcelpep  
Result Predicited by Predicited by ABCPred]

ABCpred Results

Result Predicited by Predicited by ABCPred

TPEQIDALAADMRAAS

PGRSAVPIEPDTIRAL

GTTGESPTTTDGEKIE

QRGLQAHFTAVADATE

AGAGTYDTAHSIRLAK

DGLVVSGTTGESPTTT

GIDVGDPRLPQVAATP

QIMADTGLAYYSGDDA

GTLLTAMVTPFSGDGS

TPYYSKPPQRGLQAHF

SGDIATARKINIAVAP

DVAARLGTLLTAMVTP

VGVKDAKADLHSGAQI

MLLYDIPGRSAVPIEP

PWLAMGATGFISVIAH

IEBB Analysis

Result Predicted by IEDB
Result Predicited by Predicited by IEDB