Nuclear receptor subfamily 1 group B member 3-A

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Danio rerio (Zebrafish) (Brachydanio rerio).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;Cyprinidae; Danio.

[edit] Subcellular Localization

Nucleus.

[edit] Developmental Stage

Expressed zygotically, with greatest expression at 24 hours post-fertilization (hpf).

[edit] Similarity

Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

[edit] Post translational Modification

[edit] Function

This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.