5-hydroxytryptamine 2 receptor

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 1.1 Source Organism 1.2 Taxomomy 1.3 Subcellular Localization 1.4 Developmental Stage 1.5 Similarity 2 Post translational Modification 3 Function

[edit] Description

5-HT2 receptors are a family of 5-HT receptors, with the following members:

• 5-HT_2A receptors
• 5-HT_2B receptors
• 5-HT_2C receptors

Multiple receptor subtypes of serotonin (5-HT) neurotransmitters with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of hallucinogenic effects of phenylisopropylamine hallucinogens. <ref name="entrez"> [supplied by OMIM] Template:Cite web</ref>

[edit] Source Organism

Aplysia californica (California sea hare).

[edit] Taxomomy

Eukaryota; Metazoa; Mollusca; Gastropoda; Orthogastropoda;Apogastropoda; Heterobranchia; Euthyneura; Opisthobranchia; Anaspidea;Aplysioidea; Aplysiidae; Aplysia.

[edit] Subcellular Localization

Cell membrane; multi-pass membrane protein.

[edit] Developmental Stage

[edit] Similarity

Belongs to the G-protein coupled receptor 1 family.

[edit] Post translational Modification

[edit] Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin). 5-HT plays important roles in various behavioral and physiological processes in aplysia. These include feeding, locomotion, circadian rhythm, learning and memory, synaptic plasticity, and synaptic growth. This receptor is mediated by G proteins that stimulate phospholipase C.Template:Wrongtitle