Insulin receptor7101)

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Macaca mulatta (Rhesus macaque).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.

[edit] Subcellular Localization

Membrane; Single-pass type I membrane protein.

[edit] Developmental Stage

[edit] Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain.

[edit] Post translational Modification

Autophosphorylated on tyrosine residues in response to insulin (By similarity).

[edit] Function

This receptor binds insulin and has a tyrosine-protein kinase activity.