Parathyroid hormone-related protein precursor

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

[edit] Source Organism

Oryctolagus cuniculus (Rabbit).

[edit] Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;Oryctolagus.

[edit] Subcellular Localization

Cytoplasm (By similarity). Nucleus (By similarity). Secreted protein (By similarity).

[edit] Developmental Stage

[edit] Similarity

Belongs to the parathyroid hormone family.

[edit] Post translational Modification

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).

[edit] Function

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differenciation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Osteostatin is a potent inhibitor of osteoclastic bone resorption (By similarity).