Paramethasone

From DrugPedia: A Wikipedia for Drug discovery

[edit] Description

Show 3-D Structure

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than HYDROCORTISONE with supplementary FLUDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)

[edit] General Properties

*Molecular Weight

392.46

*Molecular Formula

C₂₂H₂₉FO₅

*IUPAC NAME

(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

*Canonical Smiles

CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)CO)O)C)O)C)F

*Isomeric Smiles

C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)F

[edit] PhysioChemical Properties

*Melting Point

*LogP

1.68(EST)

*Water Solubility

[edit] External Links

• [1]Pubchem
• [2]KEGG Compound
• [3]KEGG Drug
• [4]Drugbank