Buprenorphine

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Buprenorphine
Systematic (IUPAC) name
N/A
Identifiers
CAS number	?
ATC code	?
PubChem	11969480
Chemical data
Formula	C29H42ClNO4
Mol. mass	504.10108
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Description

A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.

General Properties

*Molecular Weight

504.10108

*Molecular Formula

C₂₉H₄₂ClNO₄

*IUPAC NAME

N/A

*Canonical Smiles

CC(C)(C)C(C)(C1CC23CCC1(C4C25CCN(C3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O.Cl

*Isomeric Smiles

CC(C)(C)[C@](C)([C@H]1C[C@@]23CCC1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)O)O4)CC7CC7)OC)O.Cl

*XLogP

N/A

*Topological Polar Surface Area

62.2

External Links

• Pubchem

Link to BIAdb Database