Orphan steroid hormone receptor 2
From DrugPedia: A Wikipedia for Drug discovery
Contents |
Source Organism
Strongylocentrotus purpuratus (Purple sea urchin).
Taxomomy
Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae;Strongylocentrotus.
Subcellular Localization
Cytoplasm. Nucleus. Note=The subcellular location of isoform 1 alters throughout development. In the unfertilized egg, isoform 1 expression is cytoplasmic and concentrated around the pronucleus. Following fertilization, the cytoplasmic protein rapidly enters the embryonic nuclei where it appears as speckles. From the fourth cleavage stage onwards it resides as speckles in the cytoplasm and the nucleus. The cytoplasmic localization also differs between cells, maintaining an apical position in polarized ectodermal and endodermal cells, whereas in non-polarized cells the cytoplasmic distribution is uniform. In contrast, isoform 2 resides in the nucleus in both 4- cell and 16-cell embryos.
Developmental Stage
Expressed both maternally and zygotically. Present in the unfertilized egg and in all embryonic stages up to the pluteus stage, followed by depletion of expression in the late embryo. Expression starts again just prior to metamorphosis in larva at 35 days post fertilization. Also expressed in adults (at protein level).
Similarity
Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Post translational Modification
Function
Orphan nuclear receptor. Binds to the hormone response element in the upstream promoter region of the CYIIIB gene in vitro. Both isoform 1 and isoform 2 bind DNA.
