L-thyroxine

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

Description

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

General Properties

*Molecular Weight

776.87

*Molecular Formula

C₁₅H₁₁I₄NO₄

*IUPAC NAME

(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoicacid

*Canonical Smiles

C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N

*Isomeric Smiles

C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N

PhysioChemical Properties

*Melting Point

235.5(EXP)

*LogP

4.12(EST)

*Water Solubility

1.05E-04(EST) at 25C

External Links

• [1]Pubchem
• [2]]1ICT,[[3]]1IE4,[[4]]1HK1,[[5]]1HK2,[[6]]1HK3,[[7]]1HK4,[[8]]1HK5,[[9]]1SN0,[[10]]1Y0X,[[11]]2CEO,[[12]]2ROX,[[13]]2RIW,[[14]]1ETA,[[15]]1ETB,
• [16]KEGG Compound
• [17]Human Metabolome DataBase
• [18]Drugbank

Categories:Hormones