PolysacDB Glucurunoxylomannan 2637

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Glucurunoxylomannan

Carbohydrate Class

Miscellaneous

Source Microbe

Cryptococcus neoformans Serotype B

Basic Structure

A linear α(1-->3)- linked mannan backbone singly substituted with non-reducing β(1-->2) xylose and β(1-->2) glucuronic acid side branches ; O-acetyl groups are present at C-6 of the mannosyl residues

Proposed functions

Antiphagocytic ; an important virulence factor

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Sheep erythrocytes

Conjugation Method

The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature

Antibodies

Mab F10F5

Antibody type and class

IgG1

Assay System

ELISA

Cross-reactivity

This antibody cross-reacted with Serotypes A and B

Proposed epitopes

N/A

Proposed Utility

This antibody was used in the elucidation of the probable epitopes present in glucurunoxylomannan

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database