Desoxycortone
From DrugPedia: A Wikipedia for Drug discovery
Desoxycortone
Pubchem(6166)
21-Hydroxypregn-4-ene-3,20-dione. Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
Pathway(C03205,D07792) C21-Steroid hormone metabolism Activity Adrenal cortex hormone, mineralocorticoid
| MMDB ID | PDB ID | Reference |
|---|---|---|
| 33237 | 1Y9R | Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin MECrystal structure of a mutant mineralocorticoid receptor responsible for hypertensionNat. Struct. Mol. Biol. v12, p.554-555 |
| 34430 | 2AA7 | Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SPA ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptorJ. Biol. Chem. v280, p.31283-31293 |
| 59380 | 2Q3Y | Ortlund EA, Bridgham JT, Redinbo MR, Thornton JWCrystal structure of an ancient protein: evolution by conformational epistasisScience v317, p.1544-1548 |
Physical Property Value Units Temp (deg C) Source |Melting Point |141.5 |deg C | |EXP |- |log P (octanol-water) |2.88 |(none) | |EXP |- |Water Solubility |59.5 |mg/L |37 |EXP |- |Vapor Pressure |2.85E-10 |mm Hg |25 |EST |- |Henry's Law Constant |1.01E-08 |atm-m3/mole |25 |EST |- |Atmospheric OH Rate Constant |1.07E-10 |cm3/molecule-sec |25 |EST |- |} Organism Test Type Route Reported Dose (Normalized Dose) Effect Source |mouse |LD50 |unreported |1gm/kg (1000mg/kg) | |Journal of Medicinal Chemistry. Vol. 7, Pg. 673, 1964. |- |}
