PolysacDB 2473

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Excretory-secretory antigen [ES]

Carbohydrate Class

Miscellaneous

Source Microbe

Toxocara canis

Basic Structure

Excretory-secretory (ES) antigens of this species are composed of a restricted range of components, with overlapping but not identical profiles. The ES antigens range in m.w. from 32,000 (32 KDa) to 400 KDa and include at least one allergenic component. They are each glycoproteins, containing in all 40% by weight of carbohydrate, and differential lectin binding and protease sensitivity indicate that the major components are discrete parasite antigens rather than degradation products of common derivation

Proposed functions

N/A

Antigenic Nature used to produce antibodies

T. canis larvae

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab Tcn-2

Antibody type and class

IgM

Assay System

ELISA, immunoblotting, immunofluorescence, Immunoradiometric assay and inhibition assay

Cross-reactivity

This Mab was specific to Toxocara canis and did not react with surface-labeled antigens of the nematodes T.spiralis, Heligmososmoides polygyrus. or B. pahangi

Proposed epitopes

N/A

Proposed Utility

This Mab was able to bind to exposed sites on the epicuticle of intact Toxocara larvae

Weblink

PubMed

External Links

• Link to PolysacDB database