PolysacDB 125 Kda antigen 2393

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

125 Kda antigen

Carbohydrate Class

Miscellaneous

Source Microbe

Streptococcus mutans OMZ175 (serotype f)

Basic Structure

N/A

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Cell wall extracted antigens

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab LOSM1

Antibody type and class

IgM

Assay System

Western blotting and immunoprecipitation techniques, enzyme-linked immunosorbent assay (ELISA), and competitive ELISA

Cross-reactivity

Monoclonal antibody LOSM1 showed a quite identical reactivity with WEA from S. mutans serotypes f and b, reduced activity against WEA from serotypes c, e, and a, and weak binding to serotypes d and g

Proposed epitopes

N/A

Proposed Utility

Using this monoclonal antibody, it has been demonstrated that cross-reactivity and conservation of the specific epitopes among the various S. mutans serotypes. These Mab should be useful in studying the streptococcal surface moities

Weblink

PubMed Central

External Links

• Link to PolysacDB database