Estriol

From DrugPedia: A Wikipedia for Drug discovery

Estriol Pubchem(5756)

A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.

Drug Type: Small Molecule; Approved Pharmacology: Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.

Mechanism of Action: Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of 'unconjugated estriol' are abnormally low in a pregnant woman, this may indicate a problem with the development of the child.

Indication: Used as a test to determine the general health of an unborn fetus.

KEGG Pathway(C05141,D00185)

• Androgen and estrogen metabolism

Target estrogen receptor (ER) agonist Activity Estrogen