PolysacDB Core oligosaccharide 2294

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Core oligosaccharide

Carbohydrate Class

Core oligosaccharide [LPS]

Source Microbe

Shigella spp.

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen consists of the following residues : -3)-β-D-Quip4NAc-(1-->2)-α-D-Manp [branched to α-L-Rhap-(1-->3)] -(1-->4)-β-D-Galp-(1-->3)-α-D-GlcpNAc-(1-

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Heat killed cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 2C32E6

Antibody type and class

N/A

Assay System

Indirect ELISA

Cross-reactivity

This Mab was reactive to S. flexneri and S. boydii

Proposed epitopes

N/A

Proposed Utility

This Mab has potential importance in immunological detection of Shigella from unknown samples

Weblink

PubMed

External Links

• Link to PolysacDB database