PolysacDB O-polysaccharide 2291
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
O-polysaccharide
Carbohydrate Class
O-polysaccharide [LPS]
Source Microbe
Shigeila sonnei serotype D
Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
Proposed functions
N/A
Antigenic Nature used to produce antibodies
Heat killed cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab ShllS
Antibody type and class
IgM
Assay System
ELISA and immunoblotting
Cross-reactivity
N/A
Proposed epitopes
N/A
Proposed Utility
This Mab has been used to analyze clinical isolates and a hybrid Salmonella typhi strain for their expression of the corresponding LPS moieties. In addition to their use in the screening of candidate vaccine strains, the new MAb provide a powerful tool for epidemiological and phylogenetic studies of natural enterobacterial populations
