PolysacDB Lipopolysaccharide 2194

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Serogroup C1 (0:6,7) Salmonella

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-β-D-Manp-(1-->2)-α-D-Manp [branched to α-D-Glcp-(1-->3)] -(1-->2)-α-D-Manp-(1-->2)-α-D-Manp-(1-->3)-β-D-GlcpNAc-(1-

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

O6 coated Salmonella thompson bacteria

Carrier Name

nil

Conjugation Method

nil

Antibodies

Rat Mab 2

Antibody type and class

IgM

Assay System

ELISA

Cross-reactivity

This Mab was specific to the immunizing strain and did not react with other strains

Proposed epitopes

N/A

Proposed Utility

N/A

Weblink

PubMed

External Links

• Link to PolysacDB database