PolysacDB O-polysaccharide 2179

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Salmonella typhimurium

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -2)-α-D-Manp [branched to α-Abep-(1-->3)] -(1-->4)-α-L-Rhap-(1-->3)-α-D-Galp-(1-

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 5A5

Antibody type and class

IgM

Assay System

ELISA, immunoblotting, dot blot assay, immunoelectron microscopy

Cross-reactivity

This Mab reacted with S. typhimurium (LPS O:1, 4, 5, and 12) while failing to recognize S. typhimurium var. copenhagen (LPS O:1, 4, and 12). It reacted equally with live and heat-attenuated Salmonella B serovars containing LPS O-5 antigen

Proposed epitopes

N/A

Proposed Utility

This Mab can be used to discriminate between S. typhimurium and S. typhimurium var. copenhagen

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database