PolysacDB O-polysaccharide 2040
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
O-polysaccharide
Carbohydrate Class
O-polysaccharide [LPS]
Source Microbe
Pseudomonas aeruginosa Serotype O2
Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
Proposed functions
N/A
Antigenic Nature used to produce antibodies
Formalin killed whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab MF71-3
Antibody type and class
IgM
Assay System
ELISA, immunoblotting, ouchterlony immunodiffusion
Cross-reactivity
This Mab was specific to serotype O2
Proposed epitopes
The epitope consisted of the L-guluronic acid-(α1-->3)-D-FucNAc(β1-->4) portion of the O2-antigen
Proposed Utility
This Mab helps us shed some light on the nature of O-specific and common epitopes in the LPS of P. aeruginosa
