PolysacDB Capsular polysaccharide 1974

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Streptococcus pneumoniae strain 14

Basic Structure

The capsular polysaccharide consists of the following residues : -6)-β-D-GlcpNAc [branched to β-D-Galp-(1-->4)] -(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Tetanus toxoid

Conjugation Method

The oligosaccharide was derivatized with adipic acid dihydrazide and coupled to tetanus toxoid

Antibodies

Mab 1F2

Antibody type and class

IgG1

Assay System

Enzyme Inhibition Assay, colony blotting, Opsonophagocytosis assay

Cross-reactivity

This Mab was specific tgo strain 14 and did not cross-react with other strains

Proposed epitopes

N/A

Proposed Utility

N/A

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database