PolysacDB Lipopolysaccharide 1878
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Neisseria gonorrhoeae
Basic Structure
Gonococcal lipopolysaccharide (LPS) is a complex of at least three major antigenic determinants. The ceramide part consists of the following residues : β-D-GalpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-?)-CER-(?--/Ceramide/. The core oligosaccharide part consists of the following residues : α-D-GlcpNAc-(1-->2)-L-gro [branched to β-D-Galp-(1-->4)-β-D-Glcp-(1-->4)] -α-D-manHepp-(1-->3)-L-gro-α-D-manHepp-(1-->5)-Kdo. The other part consists of the following residues : β-D-GalpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-GlcpNAc-(1-->3)-β-D-Galp-(1-->4)-β-D-Glcp-(1-->4)-L-gro [branched to α-D-GlcpNAc-(1-->2)-L-gro-α-D-manHepp-(1-->3)] -α-D-manHepp-(1-->5)-Kdo
Proposed functions
It is an important virulence factor
Antigenic Nature used to produce antibodies
gonococcal outer membranes
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 3G9
Antibody type and class
IgG2a
Assay System
ELISA, immunoblotting
Cross-reactivity
This Mab was broadly cross-reactive among Neisseria gonorrhoeae strains except among WR213, F62, 8038-5, DAV, 6611-33, GC33 and WR302
Proposed epitopes
N/A
Proposed Utility
N/A
