PolysacDB Capsular polysaccharide 1870

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Neisseria meningitidis group B

Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues

Proposed functions

It is an important virulence factor

Antigenic Nature used to produce antibodies

Infected patient

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab SLAD

Antibody type and class

IgM

Assay System

ELISA, Rat protection assay

Cross-reactivity

This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide

Proposed epitopes

The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues

Proposed Utility

This antibody protected infant rats from bacteremia caused by Escherichia coli K1

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database