PolysacDB Capsular polysaccharide 1818

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Neisseria meningitidis group C

Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues

Proposed functions

It is an important virulence factor

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Tetanus toxoid

Conjugation Method

The oligosaccharide was activated using NaIO4 at 4C for 60 min and combined with monomeric tetanus toxoid in sodium phosphate buffer containing NaBH3CN and heated at 37C for 5 days

Antibodies

Mab C2/974.1

Antibody type and class

IgG1

Assay System

ELISA

Cross-reactivity

This Mab cross-reacted with the non-O-acetylated variant of capsular polysaccharide and also cross-reacted with E. coli K92 capsular polysaccharide

Proposed epitopes

α(2-->9)-linked sialic acid backbone seemed to be the part of the epitope

Proposed Utility

This Mab can be used for studying the capsular polysaccharide immunogenicity

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database