PolysacDB Lipoarabinomannan-B 1631

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipoarabinomannan-B

Carbohydrate Class

Miscellaneous

Source Microbe

Mycobacterium leprae

Basic Structure

Mycobacterial lipoarabinomannan is a phosphatidylinositol anchored lipoglycan that consists of an α1-->6 linked backbone, substituted to varying degrees at position 2 with single α-Man residues and directly attached to position 6 of the myo-inositol of a phosphatidylinositol (PI) anchor

Proposed functions

T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages

Antigenic Nature used to produce antibodies

soluble extract of M. leprae

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab SAl.C7F

Antibody type and class

IgG1

Assay System

Antigen capture ELISA, direct binding assay,

Cross-reactivity

This Mab was specific to M. leprae and did not cross-react with lipoarabinomannan from M. tuberculosis

Proposed epitopes

N/A

Proposed Utility

This Mab becomes applicable for monitoring several individual M . Leprae antigens such as lipoarabinomannan

Weblink

PubMed

External Links

• Link to PolysacDB database