PolysacDB Meningococcal polysaccharide group B 1576

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Meningococcal polysaccharide group B

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Neisseria meningitidis B (CN7783)

Basic Structure

It is a homopolymer of α(2-->8) sialic acid

Proposed functions

This capsular polysaccharide is an important virulence determinant. Serum antibodies to the group B polysaccharide confers protection against disease by activating complement-mediated bacteriolysis and/or opsonization. It leads to immunologic tolerance induced by prenatal exposure to host polysialyated glycoproteins

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MB-32

Antibody type and class

IgM

Assay System

radioimmunoassay, counter immunoelectrophoresis and agglutination

Cross-reactivity

N/A

Proposed epitopes

N/A

Proposed Utility

This Mab conferred very weak passive protection of mice infected with either Neisseria meningitidis group B or Escherichia coli K 1

Weblink

PubMed

External Links

• Link to PolysacDB database