PolysacDB Lipopolysaccharide 1365

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Chlamydia pneumoniae TW-183

Basic Structure

It has the core lipid A moiety and 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) core but lacks the distal O-polysaccharide region

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab CP-33

Antibody type and class

IgG2b

Assay System

N/A

Cross-reactivity

This Mab recognized the LPSs of C. pneumoniae, Chlamydia trachomatis, and Chlamydia psittaci but did not react with 15 genera of gram-negative and gram-positive bacteria and Candida albicans

Proposed epitopes

This Mab recognizes a trisaccharide epitope αKdo(2-->8) αKdo(2-->4)αKdo

Proposed Utility

This Mab neutralizes both in vitro and in vivo the infectivity of C. pneumoniae

Weblink

PubMed Central

External Links

• Link to PolysacDB database