PolysacDB Lipopolysaccharide 1189

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Yersinia enterocolitica 0:9

Basic Structure

The O-antigen part consists of the following residues : -2)-α-D-Rhap4NFo-(1-

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Killed whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Ys.T9-5

Antibody type and class

IgG1

Assay System

Whole cell agglutination, immunodiffusion, immunoblotting and ELISA

Cross-reactivity

This Mab was specific to Y. enterocolitica and did not cross-react with Brucella abortus LPS

Proposed epitopes

The epitope was proposed to be partially directed to the core that gave rise to its specificity to Y. enterocolitica. The study also indicates that the portion of the O-antigen recognized is most probably an oligosaccharide portion which encompasses elements of both the O-chain and the core

Proposed Utility

This Mab can be used to study the cell wall polysaccharide antigens of other Y. enterocolitica strains and are being evaluated for specific serological identification of B. abortus.

Weblink

PubMed Central

External Links

• Link to PolysacDB database