PolysacDB Lipopolysaccharide 1060

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Escherichia coli O157:H7

Basic Structure

-2)α-D-Rhap4NAc(1-->3)α-L-Fucp(1-->4)β-D-Glcp(1-->3)α-D-GalpNAc(1-

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 12D6

Antibody type and class

IgG3

Assay System

ELISA, immunoblotting, Fluorescent-antibody microscopy

Cross-reactivity

This antibody cross-reacted with group N Salmonella strains [(S. landau, S. soerenga, (S. urbana and S. godesberg]

Proposed epitopes

O-antigen was proposed to be the epitope

Proposed Utility

This Mab provide a valuable tool for the rapid detection of E. coli O157

Weblink

[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC229650 &tool=pmcentrez&rendertype=abstract PubMed Central]

External Links

• BCSDB Structural Detail

• Link to PolysacDB database