PolysacDB Lipopolysaccharide 1057

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Escherichia coli O26:H11

Basic Structure

The O-polysaccharide is composed of trisaccharide repeating units having the following structure. -->3)-α-L-Rhap-(1-->4)-α-L-FucpNAc-(1-->3)-β-D-GlcpNAc-(1-->

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 12F5

Antibody type and class

IgM

Assay System

ELISA, immunoblotting

Cross-reactivity

This antibody cross-reacted with E. coli O4:NM strain and other E. coli O-negative:NM field isolates

Proposed epitopes

O-antigen was proposed to be the epitope

Proposed Utility

These MAb have a potential use as immunodiagnostic reagents whether used alone or in combination with other phenotypic or genotypic markers

Weblink

[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC92269 &tool=pmcentrez&rendertype=abstract PubMed Central]

External Links

• BCSDB Structural Detail

• Link to PolysacDB database