PolysacDB Phosphocholine 1041

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Phosphocholine

Carbohydrate Class

Miscellaneous

Source Microbe

Pneumococcal strain WU(12)

Basic Structure

Phosphocholine (PC) is an intermediate in the synthesis of phosphatidylcholine in tissues. Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP + Choline into Phosphocholine and ADP

Proposed functions

Phosphocholine is determinant of lipotechoic acids of Gram positive bacteria

Antigenic Nature used to produce antibodies

Cell extract and heat killed Pneumococcal strain EF3296.

Carrier Name

nil

Conjugation Method

nil

Antibodies

SR4W1

Antibody type and class

IgG2a

Assay System

Blood bactericidal assay, hemolytic activity

Cross-reactivity

N/A

Proposed epitopes

Phosphocholine

Proposed Utility

Monoclonal antibody SR4W1 can protect mice against Pneumococcal infections.

Weblink

PubMed Central

External Links

• Link to PolysacDB database