From DrugPedia: A Wikipedia for Drug discovery

Rv2122c
Name
Phosphoribosyl-ATP pyrophosphatase (hisE)
Identifiers
Swiss Prot	P0A5B1
Genbank	888671
PDB	1Y6X
Chemical data
Formula	C19H15FO5 [1]
Mol. wt.	10243 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	4.3758

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

General

THOUGHT TO BE INVOLVED IN HISTIDINE BIOSYNTHESIS. Other PDBid: 3C90

Rv2122c, (MTCY261.18), len: 93 aa. Probable hisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (see citation below), similar to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP cyclohydrolase (230 aa), FASTA scores; opt: 150, E(): 4e-08, (37.9% identity in 87 aa overlap); etc. Note that previously misnamed hisI. DNA microarrays indicate repression by iron and IdeR|Rv2711 in M. tuberculosis H37Rv (See Rodriguez et al., 2002). Essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003) mutants available at TARGET website

Protein Sequence

>Rv2122c, TB.seq 2380664:2380942 MW:10243 VQQSLAVKTFEDLFAELGDRARTRPADSTTVAALDGGVHALGKKLLEEAGEVWLAAEHESNDALAEEISQLLYWTQVLMI SRGLSLDDVYRKL

Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q8TC76.1	42	71	28	0.71
sp|Q8NI51.1	26	47	80	2.4
sp|Q6EKJ0.1	36	56	30	6.8
sp|Q86UP8.2	36	56	30	7.3
sp|Q6ZS81.3	20	36	60	7.6

Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

Subcellular Location

Link to TBpred
Cytoplasmic

Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

B cell Epitopes

BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

IEDB Analysis

Link to IEDB
Result Predicited by [4]

MHC Class-I Binder

nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

IEDB Analysis

Link to IEDB
Result Predicted by [6]

MHC Class-II Binder

Propred Analysis

Link to Propred
Result Predicted by [7]

NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.