CarboDB Lipopolysaccharide 2516
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Vibrio cholerae 01 serogroup Inaba strain X19203
Basic Structure
The O-antigen part consists of (1-->2)-α-linked 4-amino-4,6-dideoxy-D-mannose (perosamine) whose amino group is acylated with 3-deoxy-L-glycero-tetronic acid. The terminal sugar in the Inaba O-antigen has a hydroxyl at the 2' position
Proposed functions
V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodies
Killed cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab IH 3
Antibody type and class
IgG3
Assay System
slide agglutination, microdilution agglutination, and passive hemagglutination tests
Cross-reactivity
This Mab showed almost identical reactivities to both the Ogawa- and the Inaba-type cells
Proposed epitopes
N/A
Proposed Utility
This Mab will be a very useful tool for resolution of the antigenic structure of V. cholerae 01, especially the Inaba-specific determinant
