CarboDB Capsular polysaccharide 1862
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Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Carbohydrate Name
Capsular polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Neisseria meningitidis group B
Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
Proposed functions
It is an important virulence factor
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 10C11
Antibody type and class
IgG2a
Assay System
ELISA and bactericidal assays
Cross-reactivity
This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes
The epitope consisted of α2-8 linked sialic acid residues
Proposed Utility
This Mab had bactericidal activity
