CarboDB Capsular polysaccharide 1807
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Revision as of 00:00, 15 January 2001 by Special:Contributions/ (Talk)
Carbohydrate Name
Capsular polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Neisseria meningitidis group B
Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
Proposed functions
It is an important virulence factor
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 30H12
Antibody type and class
IgG2a
Assay System
ELISA and bactericidal assays
Cross-reactivity
This Mab was specifc to Neisseria meningitidis group B and did not cross-react with group A and group C N. meningitidis capsular polysaccharides. This Mab did not recognized N-propionylated capsular polysaccharide of group B meningitidis
Proposed epitopes
α[2-->8] linked N-acetyl neuraminic acid residues seemed to be the part of the epitope
Proposed Utility
This Mab had potent bactericidal activity
