CarboDB Phenolic glycolipid antigen 1641
From DrugPedia: A Wikipedia for Drug discovery
Carbohydrate Name
Phenolic glycolipid antigen
Carbohydrate Class
Miscellaneous
Source Microbe
Mycobacterium leprae
Basic Structure
It consisting of terminal 3,6-di-O-methyl glucose linked β1-->4 to 2,3-di-O-methyl rhamnose, which in turn is linked α1-->2 to 3-O-methyl rhamnose
Proposed functions
It has been proposed to protect pathogenic mycobacteria such as Mycobacterium lepraemurium from the host bactericidal activities in phagocytic cells
Antigenic Nature used to produce antibodies
Partially purified phenolic glycolipid from M. leprae
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab B9D
Antibody type and class
IgM
Assay System
ELISA, TLC autoradiography and immunofluorescence
Cross-reactivity
This Mab cross-reacted with M. kansasii phenolic glycolipid and cross-reacted with whole cells of 20 mycobacterial strains
Proposed epitopes
Terminal 3,6-di-O-methyl glucose residues were proposed to be a part of the epitope
Proposed Utility
This Mab may provide more information on the structure of phenolic glycolipid of M. leprae and the localization of this antigen can be performed within infected lesions by immunofluorescence
