CarboDB FVP2 polysaccharide 1452

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

FVP2 polysaccharide

Carbohydrate Class

Miscellaneous

Source Microbe

Flammulina velutipes

Basic Structure

Consists of an α-(1-->4)-D-glucan, branching with a single α-D-glucan at the C-6 position to every seven residues along the main chain

Proposed functions

FVP2 can enhance the livability of primary culture of mouse hepatocytes in vitro and decrease the release of the alanine aminotransferase (ALT) as well as apoptosis of hepatocytes after the carbon tetrachloride (CCl4) intoxication. Furthermore, FVP2 has the capability of suppressing the growth of hepatoma 22 cells and sarcoma 180 cells (S180), extending the survival time of L615 leukemia mice, and promoting the lymphocyte transformation rate, natural killer cell activity, and the interleukin-2 production index in normal and tumor-bearing (S180) mice

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Bovine serum albumin

Conjugation Method

The FVP2 polysaccharide was conjugated to BSA using 1-cyano-4-dimethyl-aminopyridinium tetrafluoroborate (CDAP) treatment

Antibodies

Mab I6D

Antibody type and class

IgM

Assay System

Indirect ELISA, Double Immunodiffusion

Cross-reactivity

N/A

Proposed epitopes

N/A

Proposed Utility

This Mab provides a potentially useful tool for further study in the development of a novel and efficient immunoassay to detect FVP2 in biological specimens

Weblink

PubMed

External Links

• Link to CarboDB database