CarboDB Gp40 glycoprotein 1377

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Gp40 glycoprotein

Carbohydrate Class

Miscellaneous

Source Microbe

Cryptosporidium parvum

Basic Structure

N/A

Proposed functions

N/A

Antigenic Nature used to produce antibodies

Fixed Cryptosporidium parvum sporozoites

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 4E9

Antibody type and class

IgM

Assay System

Immunofluorescence, immunoblotting

Cross-reactivity

This Mab did not react other protozoa (Giardia lamblia, E. Histolytica, Toxoplasma gondii, Trypanosoma cruzi, and L. major) and was specific for Cryptosporidium

Proposed epitopes

The epitope recognized by 4E9 contains α-N-acetylgalactosamine residues, which are present in a mucin-type O-glycosidic linkage

Proposed Utility

This MAb neutralized C. parvum infection and inhibited sporozoite attachment to intestinal epithelial cells in vitro

Weblink

PubMed Central

External Links

• Link to CarboDB database