CarboDB Lipopolysaccharide 1163

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Bordetella pertusis

Basic Structure

B. pertusis LPS is resolved electrophoretically into two bands, a slowly migrating band designated LOS A and a fast-migrating band designated LOS B. These two species differ in molecular weight as three N-acetyl amino sugars found on LOS A are not present on LOS B

Proposed functions

The LOS of B. pertussis exhibits biological activities similar to those of endotoxins from other gram-negative bacteria, including pyrogenicity, toxicity, induction of the Shwartzman reaction, induction of tumor necrosis factor production, and adjuvant properties

Antigenic Nature used to produce antibodies

Whole cells of Bordetella Pertusis

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab HBp2

Antibody type and class

IgM

Assay System

Dot enzyme Immunoassay, Immunoblotting

Cross-reactivity

This antibody reacted with all B. pertusis strains. also cross-reacted with a clinical isolate of B. bronchiseptica. No cross-reaction was observed against B. parapertussis and other gram-negative species

Proposed epitopes

N/A

Proposed Utility

Mab HBp2 showed high lytic capability against B. pertussis

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to CarboDB database