CarboDB CA antigen 1128

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

CA antigen

Carbohydrate Class

Miscellaneous

Source Microbe

Aspergillus fumigatus 2085

Basic Structure

Galactomannans are composed of an α-1,6-linked mannan backbone substituted with mannopyranose oligosaccharides and immunodominant terminal galactofuranose present either singly or linked to oligogalactosides

Proposed functions

The wide distribution and similar chemical structure of the galactomannans have been responsible for serologic cross-reactions

Antigenic Nature used to produce antibodies

Cell walls of A. fumigatus 2086

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab SC40

Antibody type and class

IgG

Assay System

Enzyme Immunoassay, Precipitin reactions, Immunoblotting, Immunofluorescence assays

Cross-reactivity

MAb SC40 was reactive with other Aspergillus species, Fusarium sp., and dermatophytes.also cross-reacted to mannans of Candida albicans serotype A and B, C.tropicalis

Proposed epitopes

Galactomannan residues seemed to be the part of immunodominant region

Proposed Utility

These MAbs will be useful as immunoprobes for studying epitopes responsible for the shared antigenicity of fungal mannans and galactomannans and for examining their expression during hyphal and conidial morphogenesis

Weblink

PubMed Central

External Links

• Link to CarboDB database