CarboDB Capsular polysaccharide A 1026

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide A

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Cryptococcus neoformans

Basic Structure

The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated

Proposed functions

The capsular polysaccharide is an important virulence factor

Antigenic Nature used to produce antibodies

Glycoconjugates

Carrier Name

Sheep erythrocytes

Conjugation Method

The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature

Antibodies

Mab 1255

Antibody type and class

IgG1

Assay System

Ouchterlony double immunodiffusion, Phagocytosis assays

Cross-reactivity

This antibody cross-reacted with 3 serotypes- A, B and D

Proposed epitopes

The reactivity of this antibody required an intact carboxyl group and also required deacetylation of the parent polysaccharide

Proposed Utility

MAb against an epitope shared by all four serotypes may have value for the detection of cryptococcal antigens in body fluids. This antibody also has potent opsonic activity

Weblink

PubMed Central

External Links

• Link to CarboDB database