Mtb cell wall

From DrugPedia: A Wikipedia for Drug discovery

The cell wall consists of several layers (from outer, see picture right):

Contents 1 1. Phthiocerol Dimycocerosates (DIM) 2 2. Mycolic acids 3 3. Arabinogalactan 4 4. Peptidoglycan 5 5. Plasma membrane (?) 6 6. Lipoarabinomannan 7 7. Phosphatidylinositol Mannoside 8 References

1. Phthiocerol Dimycocerosates (DIM)

2. Mycolic acids

Mycolic acids are the longest fatty acids known from nature. They feature also cyclopropane residues in the chain which is unusual. Shown below are the five types of mycolic acids found in Mtb.

3. Arabinogalactan

4. Peptidoglycan

5. Plasma membrane (?)

6. Lipoarabinomannan

7. Phosphatidylinositol Mannoside

References

• Glickman MS, Cahill SM, Jacobs WR (January 2001). "The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase". J. Biol. Chem. 276 (3): 2228–33. DOI:10.1074/jbc.C000652200. PMID 11092877.