Differences between Mtu strains

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There are several ways to look at pairwise differences between Mtu strains:

  • pairwise differences in the nucleotids of the genomes
  • pairwise differences in the amino acid sequences
  • pairwise proteomic differences (orthologs, missing genes, gene doubling, additions like prophages)
  • pairwise functional differences where known

Since we now have complete genomes of several strains of Mtu, and we have pairs of orthologs for both from a highly accurate algorithm (OMA), and the highly correct phylogenetic trees from OMA show us which strains are nearest, we can most easily give orthologs and paralogs between nearest pairs of strains.

name H37Ra F11 (H37Rv) function
number of genes 3990 3855
1:1 orthologs 3725 see this file
1:n orthologs 0
n:1 orthologs 12
n:m orthologs 40
2:1 MRA_0985, MRA_0987 TBFG_00968 (Rv00980c, Rv00986c) PE-PGRS family proteins
2:1 MRA_1598, MRA_3507 TBFG_03453 (Rv1587c) REP13E12 repeat protein; (Rv3467) unchar.