Diflorasone diacetate

From DrugPedia: A Wikipedia for Drug discovery

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Diflorasone is a corticosteroid that comes in the form of a cream containing diflorasone diacetate. According the drug's maker, E. Fougera & Co., it is used for its anti-inflammatory and anti-itching qualities, like other topical corticosteroids. It is often prescribed for psoriasis and atopic dermatitis, and also for Hailey Hailey Disease (Familial Benign Pemphigus). and is considered to be of greater potency compared to other topical corticosteroids.

No long-term animal studies have been done to determine whether diflorasone could have carcinogenic properties.

Women who are breastfeeding their newborns should probably not use diflorasone since corticosteroids have been known to appear in breast milk and cause negative effects in a newborn, such as inhibited growth, but little data is available regarding whether topical corticosteroids like diflorasone would be present in great enough quantities to cause harm to an infant.

[edit] General Properties

*Molecular Weight

494.52

*Molecular Formula

C₂₆H₃₂F₂O₇

*IUPAC NAME

[(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate

*Canonical Smiles

CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)OC(=O)C)C)O)F)C)F

*Isomeric Smiles

C[C@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)OC(=O)C)C)O)F)C)F

[edit] External Links

• [1]Pubchem
• [2]]KEGG Drug
• [3]Drugbank