Coumestrol
From DrugPedia: A Wikipedia for Drug discovery
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Description
A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.Daidzein is one of several known isoflavones. Isoflavones compounds, such as daidzein and genistein, are found in a number of plants and herbs like the Thai Kwao Krua or Pueraria Mirifica, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Soy isoflavones are a group of compounds found in and isolated from the soybean. Besides functioning as antioxidants, many isoflavones have been shown to interact with animal and human estrogen receptors, and are therefore known as phytoestrogens. Soy isoflavones also produce non-hormonal effects.
Isoflavones act as antioxidants to counteract damaging effects of free radicals in tissues. Isoflavones can act like estrogen in stimulating development and maintenance of female characteristics or they can block cells from using other forms of estrogenTemplate:Fact. Isoflavones also have been found to have antiangiogenic effects (blocking formation of new blood vessels)Template:Fact, and may block the uncontrolled cell growth associated with cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors)Template:Fact.
Studies show that groups of people who eat large amounts of soy-based products have lower incidences of breast, colon, endometrial, and prostate cancers than the general (US) populationTemplate:Fact. Initial studies of soy and Kwao Krua isoflavone mixtures containing genistein, daidzein, and glycitein have found them safe for human use<ref>Safety of soy-based infant formulas containing isoflavones PMID 15113975</ref>. Laboratory studies using animals models have shown that both soy and isoflavones can be protective against cancer when given during early life but can stimulate response to cancer-causing chemicals when given during fetal development or when circulating levels of estrogen are low (menopause)Template:Fact.
Pueraria mirifica or White Kawo Krua has been found to contain concentrations of daidzein where the Cu²+ at 300 ppm is shown to contain as much as 44.69 ppm of daidzein. Another source of daidzein is Kudzu also known as Pueraria Lobata.
General Properties
*Molecular Weight
268.22
*Molecular Formula
C15H8O5
*IUPAC NAME
3,9-dihydroxy-[1]benzoxolo[3,2-c]chromen-6-one
*Canonical Smiles
C1=CC2=C(C=C1O)OC3=C2C(=O)OC4=C3C=CC(=C4)O
*Isomeric Smiles
PhysioChemical Properties
*Melting Point
385(EXP))
*LogP
1.57(EST)
*Water Solubility
