PolysacDB Lipopolysaccharide 2554

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Vibrio cholerae serogroup O139

[edit] Basic Structure

N/A

[edit] Proposed functions

V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera

[edit] Antigenic Nature used to produce antibodies

Whole cell lysates

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 12F5-G11

[edit] Antibody type and class

IgG2b

[edit] Assay System

dot-blot ELISA, immunoblotting, ELISA

[edit] Cross-reactivity

This Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database