PolysacDB Lipopolysaccharide 2551

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Vibrio cholerae 01 35 Inaba

[edit] Basic Structure

The O-antigen part consists of (1-->2)-α-linked 4-amino-4,6-dideoxy-D-mannose (perosamine) whose amino group is acylated with 3-deoxy-L-glycero-tetronic acid. The terminal sugar in the Inaba O-antigen has a hydroxyl at the 2' position

[edit] Proposed functions

V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera

[edit] Antigenic Nature used to produce antibodies

Purified LPS

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab H4

[edit] Antibody type and class

IgM

[edit] Assay System

enzyme-linked immunosorbent assay inhibition experiments

[edit] Cross-reactivity

This Mab reacted with Ogawa 34 and Inaba 35 serotype LPS but did not react with O2 LPS

[edit] Proposed epitopes

This Mab was specific to A antigen. Epitope A was postulated to be either the perosamine residues or the N-tetronic acid (N-3-deoxy-L-glycero-tetronic acid) side chain

[edit] Proposed Utility

This Mab had a good agglutinating capacity when tested against V. cholerae 0:1 strains

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database