PolysacDB Lipopolysaccharide 2442
From DrugPedia: A Wikipedia for Drug discovery
[edit] Carbohydrate Name
Lipopolysaccharide
[edit] Carbohydrate Class
Lipopolysaccharide
[edit] Source Microbe
Shigella flexneri serotype Y
[edit] Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen part consists of the following residues : -3)-α-D-GlcpNAc-(1-->3)-β-L-Rhap-(1-->2)-α-L-Rhap-(1-->2)-β-L-Rhap-(1-
[edit] Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
[edit] Antigenic Nature used to produce antibodies
Phenol killed cells
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab Y-B2
[edit] Antibody type and class
IgG3
[edit] Assay System
ELISA, immunodiffusion
[edit] Cross-reactivity
This Mab cross-reacted with 1a and 4a LPS
[edit] Proposed epitopes
This Mab reacted with alkali-treated LPS and O-antigen. Mab Y-B2 exhibits distinct preference for the oligosaccharide α-L-Rha(1-->2)α-L-Rha(1-->3)α-L-Rha(1-->3)βGlcNac repeating as a dimer
[edit] Proposed Utility
This Mab can be used for antigenic characterization of Shigella LPS
