Estradiol

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

Description

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the PLACENTA. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (RECEPTORS, ESTROGEN) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

General Properties

*Molecular Weight

272.38

*Molecular Formula

C₁₈H₂₄O₂

*IUPAC NAME

(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

*Canonical Smiles

CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

*Isomeric Smiles

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O

PhysioChemical Properties

*Melting Point

178.5(EXP)

*LogP

4.01(EXP)

*Water Solubility

3.6(EXP) at 27C

External Links

• [1]Pubchem
• [2]]1QKT,[[3]]1QKU,[[4]]1JGL,[[5]]1G50,[[6]]1JNN,[[7]]1GWR,[[8]]1LHU,[[9]]1PCG,[[10]]2D06,[[11]]2J7X,[[12]]1A52,[[13]]1AQU,[[14]]1IOL,[[15]]1A27,[[16]]1FDS,[[17]]1FDT,[[18]]1FDW,[[19]]2OCF,[[20]]1ERE,
• [21]KEGG Compound
• [22]KEGG Drug
• [23]Human Metabolome DataBase
• [24]Drugbank

Categories:Hormones