PolysacDB Lipopolysaccharide 1078

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Escherichia coli O18:K1:H7

[edit] Basic Structure

N/A

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 109

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, invitro opsonophagocytosis assay, immunoblotting, invivo protection studies

[edit] Cross-reactivity

This Mab cross-reacted with other 018 E. coli strains but were unreactive with heterologous 0 serotypes (e.g., 075 E. coli), E. coli J-5 Rc, Salmonella typhimurium Re rough mutants, or other gram-negative bacteria.

[edit] Proposed epitopes

The epitope was proposed to consist of the O-antigen

[edit] Proposed Utility

This Mab showed partial protection in invivo models

[edit] Weblink

[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC261046 &tool=pmcentrez&rendertype=abstract PubMed Central]

[edit] External Links

• Link to PolysacDB database