PolysacDB Capsular polysaccharide D 1027

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular polysaccharide D

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Cryptococcus neoformans

[edit] Basic Structure

The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated

[edit] Proposed functions

The capsular polysaccharide is an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Sheep erythrocytes

[edit] Conjugation Method

The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature

[edit] Antibodies

Mab 302

[edit] Antibody type and class

IgG1

[edit] Assay System

Ouchterlony double immunodiffusion, Phagocytosis assays

[edit] Cross-reactivity

This antibody cross-reacted with 2 serotypes- A and D

[edit] Proposed epitopes

The reactivity of this antibody required acetylation of the parent polysaccharide. Hence proposed epitopes may be O-acetyl groups

[edit] Proposed Utility

MAb against an epitope shared by all four serotypes may have value for the detection of cryptococcal antigens in body fluids. This antibody also has potent opsonic activity

[edit] Weblink

PubMed Central

[edit] External Links

• Link to PolysacDB database